Moises Exposito-Alonso named a member of the 2024 class of Forbes’ 30 Under 30 Europe list in science and healthcare

Out of the thousands of nominees, the 30 finalists in each of the 10 categories comprise “the world’s most impactful community of young entrepreneurs and game-changers,” said the publication in announcing his selection.  

“Growing up in southern Spain, I saw how Mediterranean forests may be transformed by climate change into arid deserts,” said Moi. “My childhood desire to halt this destructive trend manifested in a career pursuing the answers to fundamental questions about genetics, ecology, and evolution, which I believe are key to solving the global biodiversity crisis.”

Moi received his PhD at the end of 2018 for work on plant adaptation to climate change. Today, he leads a team at the Carnegie Institution that conducts large-scale ecological and genome sequencing experiments to generate maps of a species’ genomic susceptibility to climate change that may guide policymakers and management efforts in how to respond to this global challenge.   

Atypical Resistance Protein RPW8/HR Triggers Oligomerization of the NLR Immune Receptor RPP7 and Autoimmunity

Lei Li et al., Cell Host Microbe, published Feb 26, 2024. http://doi.org/10.1016/j.chom.2024.01.012

In certain plant hybrids, immunity signaling is initiated when immune components interact in the absence of a pathogen trigger. In Arabidopsis thaliana, such autoimmunity and cell death are linked to variants of the NLR RPP7 and the RPW8 proteins involved in broad-spectrum resistance. We uncover the molecular basis for this autoimmunity and demonstrate that a homolog of RPW8, HR4 Fei-0, can trigger the assembly of a higher-order RPP7 complex, with autoimmunity signaling as a consequence. HR4 Fei-0-mediated RPP7 oligomerization occurs via the RPP7 C-terminal leucine-rich repeat (LRR) domain and ATP-binding P-loop. RPP7 forms a higher-order complex only in the presence of HR4 Fei-0 and not with the standard HR4 variant, which is distinguished from HR4 Fei-0 by length variation in C-terminal repeats. Additionally, HR4 Fei-0 can independently form self-oligomers, which directly kill cells in an RPP7-independent manner. Our work provides evidence for a plant resistosome complex and the mechanisms by which RPW8/HR proteins trigger cell death.

"The 2024 Novozymes Prize is being awarded to Professor Detlef Weigel (photo) for his outstanding research contributions that have led to groundbreaking new knowledge of the genetic structure of plants. His work has had major impact on developing innovative biotechnological solutions for crop improvement and understanding how plants adapt to the environment. The Novo Nordisk Foundation awards the Prize, which is accompanied by DKK 3 million."

The American Society of Naturalist's Young Investigator Award goes to applicants who completed their PhD three years preceding the application deadline or are in their last year of a PhD program.